Reversing Ageing: New Studies Show it Can be Done
hi welcome to another ColdFusion video aging is a part of everyday life it’s guaranteed to happen to everyone eventually we all get old develop diseases slow down and eventually die of old age we all understand it but what if we actually don’t understand it and what if things didn’t have to be this way what if we could slow down the clock and even turn it back well researchers are developing ways to unlock the tools within our own body to help us do exactly that in this video we’ll take a look at something a little different health regeneration let’s get into you are what will ColdFusion TV these are two mice one looks young and healthy the other decrepit and old but these mice were actually born on the same day in fact they’re twins dr.
Sinclair at Harvard Medical School led a team of researchers in this experiment the goal was altering the epigenome in the DNA in one of these mice so what is an epigenome in short it’s responsible for coiling up and turning on and off parts of a DNA string as required depending on the parts of the DNA that is turned on and off means the difference between creating a skin cell versus a nerve cell our DNA is effectively the code which tells ourselves what to be as we age researchers believe that our DNA epigenomes unravel and other parts that weren’t meant to be quelled becomes so effectively our bodies begin to create the wrong cells in the wrong places this deterioration of epigenetic information is what dr.
Sinclair’s team accelerated in one of the mice therefore one Mouse literally aged faster than its twin aging is in fact something that our DNA tracks very accurately and quantitatively this is how it’s done DNA is made up of four different components called nucleobases they are a C T and G and they’re paired together to make the famous double helix structure over the course of our lifetime methyl groups which are just a carbon with three hydrogen’s begin to attach to the C components of our DNA by measuring your DNA through a blood sample or a mouth swab scientists with the help of AI can tell exactly how old you are based on how many methyl groups you have this is called the Horvath clock it’s extremely accurate and can even predict when you’ll die this is a recent discovery and it’s not just an accurate measure of biological age researchers believed that the clock itself is part of the aging mechanism hence physically being able to dial back the hands of the clock could mean becoming physically younger however this appears to be one of many interconnected mechanisms that control aging the analogy is by dr.
Sinclair is that our epigenetic information is lost over our lifetime much like a CD gets scratched over time and begins to glitch the old theory was that our DNA information gets lost over time as we succumb to entropy in the old theory the damage comes through free radicals oxidization DNA mutations and damage dr.
Sinclair believes that we should throw that theory out it’s not the loss of DNA itself but the on and off switches on our DNA so is there a way to polish our genetic CD and get the information back and if we push the reset button how many times can we do it is there a limit well there’s some promising research being carried out the doctor and his team were much more interested in reversing the processes of aging rather than inducing it what would come after the initial mouse experiment could prove to be a revolutionary step again these are two mice on a treadmill both at 20 months old the equivalent of approximately 70 human years but one has been treated with a chemical compound known as nmn if he guessed the mouse on the right you’d be correct treated mice ran on average 430 meters compared to the untreated control group which ran 240 meters as the experiments progressed some peculiar things began to happen the mice that we treated within a man they just ran and ran and ran they actually broke the little treadmill in my lab because they ran so far and I get a text from the researcher hey the machine broke and I said check the software and turns out software was written to stop it three kilometers because my mouse had run that far before that’s long and those are old mice don’t forget these are mice the equivalent of the equivalent of a 65 year old human they ran and ran around they didn’t get lactate build-up as much as didn’t feel tired these chemical compounds all help increase something called nad levels in the body dr.
Sinclair’s research is trying to link NID with ageing nad is central to the metabolic system helping carry electrons between reactions within all living cells Sinclair and his team are testing nad boosting drugs on the elderly and hoping to get FDA approval for yeast and diseases in the next three years other factors apart from specific drugs that boost nad levels are natural things such as exercise a good diet and even fasting which dr.
Sinclair practices himself so to be clear living a healthy lifestyle naturally boosts your nad levels but it’s the drug component of increasing nad levels that is potentially a game-changer however there’s understandably some controversy around so-called Fountain of Youth pills some saying current research doesn’t back up the claims others using anecdotal evidence to the contrary while there is evidence to show that the use of compounds such as M&M increase nad levels in the body there still isn’t concrete evidence that nad levels increased longevity and human trials are still ongoing there is however a decline of nad levels with age and this was the spark that turned researchers to focus on nad as a proponent of aging with time we will see if the trials and Myers can be carried over to humans but this all doesn’t end there another interesting discovery which may be fundamental to getting humans to be able to regenerate their bodies is something called the Yamanaka factors these are named after the Nobel Prize winner dr.
Yamanaka he used these factors to convert human adult cells into stem cells effectively a blank canvas to be used anywhere in the body dr. Sinclair’s team attached some of the in Monaca factors to a benign virus and then injected it into two mice the researchers pinched an optical nerve in the eye of both mice effectively crushing it now young cells will regenerate and heal themselves while old cells will struggle some species even have the ability to grow entirely new limbs what if there was a way to find the part of our epigenome responsible for regrowing damaged or lost parts of our bodies and then turn it on more on this later back to the experiment the effect of the emmenecker factor virus can be seen the top image shows no treatment and the cells don’t regenerate and fix themselves the bottom image shows a treated Mouse the cells in this Mouse actually begin to grow back towards the eye and within 16 weeks they repair entirely could this eventually be a key to treating degenerative diseases for example poor vision due to age perhaps this technology could repair the eyesight of the elderly and maybe even injuries like spinal injuries it’s interesting to think about dr.
Sinclair explains that at least in mice researchers know that they can positively improve vision the cells that were old began to wake up they begin to remember that they are a photoreceptor cell and not a half skin cell they are measurably younger parts of their genome that are meant to be on are turned on and the parts that are meant to be off are coiled up and even if this is true just for mice it really is amazing we find that with our reprogramming we can make the nerves be just like a newborn baby they grow back and then we also tested on glaucoma pressure in the eye we increased pressure in the mouse’s eye and they lose their largely thir eyesight and we can recover that and then we also a test old mice that don’t see very well and we also seem to improve their eyesight almost back to normal so what I I don’t think we’ll be going to nursing homes any time soon but what we are doing is running a clinical trial on this and so we’re looking to do that in early 2020 and the clinical trial will be on people with glaucoma or various eye issues the plan is glaucoma first but it could work for other damaged retinas as well even broken spinal cords what we’re thinking of trying the ability to turn on or off specific parts of the genome is a very interesting proposition we can turn off parts of our genes which may cause genetic diseases so in conclusion dr.
Sinclair’s work is on the cutting edge of research into the aging process while he doesn’t claim to have found the Fountain of Youth his research is very promising and could lead to some very inspirational outcomes at the very least we could help improve health for those later in life this would give people a better quality of life in their final decades but interestingly it could also save trillions of dollars in the long run as there would be much less of a burden on our healthcare systems but at best we could unravel the secrets to our own bodies discovering parts in our DNA we never knew existed we could help reverse diseases that are incurable today and live longer and healthier too this field is a rapidly evolving one and right now is still in the research stage it will probably be decades before this technology if even possible will become available for widespread use regardless is still interesting to see how such new fields of research are emerging of course there should be some caution in how we proceed when it comes to modifying genetics but for increasing nad levels at least that doesn’t seem to be much of a downside and that’s probably because nad is a natural chemical that comes from a healthy diet and exercise if we do in fact get there this could turn out to be one of the most pivotal things the human race has ever done I’ll be watching this space with every action we assume there’s some negative consequence or potentially negative consequence right we always assume that but it’s not always right mmm so it with the molecules that we’ve been testing for years now like in a man we haven’t seen any downside just longer endurance and protection so there isn’t always a downside to these things in fact if you just think any man is replacing a molecule that we lose over time as you get older it’s just becoming you know it’s fairly natural process no downside exercising and dieting I hope you enjoyed that video or at least found it interesting if you’re interested in science technology business or history feel free to subscribe to this channel I’m sure you’ll find some interesting stuff on here alright so my name is – gogo and you’ve been watching cold fusion I’ll see you again soon for the next episode cheers guys have a good one cold fusion it’s me thinking